The 37-year-old Mikel Arteta played for Arsenal from 2011 to 2016 before moving to Manchester City as assistant manager, where he won the Premier League twice.
Colombian super-sub Jhon Duran scored two late goals as Aston Villa salvaged a 3-3 home draw with Liverpool.
The 32-year-old World Cup-winner, who was among the highest-paid players at the London club, has not played since March.
A summary of Wednesday's Champions League Round of 16, Second Leg, matches.
IMAGES from the Premier League matches played across England, on Sunday.
A round-up of Saturday's action in the Premier League.
IMAGES from the Premier League matches played on Saturday.
The result leaves Ole Gunnar Solskjaer's United in 10th with nine points, their worst start after seven games for 30 years, and they have won just one of their last six league games.
Barcelona retained the King's Cup with a 2-0 victory over Sevilla to complete a domestic double.
IMAGES from UEFA Champions League matches played on Tuesday
PSG coach Unai Emery said he wanted to be optimistic that his 222-million euro ($273 million) signing would be available to face Real as the French league leaders bid to overcome a 3-1 deficit to avoid an early exit from the tournament.
Arsenal have signed forward Nicolas Pepe from French club Lille for a club-record fee, the Premier League side said on Thursday.
Brazil forward Neymar denied he had problems with his team mates at his club Paris St Germain and was moved to tears after being given the backing of his national team coach Tite.
Edinson Cavani silenced his critics when he scored four goals in Paris St Germain's 6-0 victory at Caen in Ligue 1 on Friday.
Manchester United's Alejandro Garnacho scored with a magical overhead kick in the third minute to send the visitors on their way to a 3-0 victory over an Everton team already reeling in their first Premier League game after being docked 10 points.
Manchester City manager Pep Guardiola denied reports that his contract contains a 'break clause' that could allow him to leave at the end of the season. The Spaniard signed an extension last year until 2021 but with City's hopes of a third successive Premier League title now looking remote, questions have been raised about his future.
Manchester United languish 14th in the standings on 19 points, their worst placing to end a calendar year since they were 15th in 1989.
Paris St Germain suffered their second defeat of the Ligue 1 season when they lost 2-0 at Toulouse after being reduced to 10 men on Friday.
Arsenal returned to the top of the Premier League with a comfortable 2-0 victory over relegation-threatened Luton Town
After a tense encounter finished 1-1 following extra time, Villareal's Rulli stepped up after every on-field player scored their spot kicks and he comfortably beat Spaniard De Gea
Holders Sevilla swept into a second consecutive Europa League final.
The former Arsenal forward rules out Germany return.
An own goal and a Sadio Mane strike earned Liverpool a 2-0 victory in their Champions League semi-final first-leg against Villarreal on Wednesday, putting Juergen Klopp's side on course for their third European Cup final in five seasons.
IMAGES from the English Premier League matches played on Wednesday
Sevilla coach Unai Emery has been picking the brains of Juande Ramos as he tries to plot the downfall of Ukrainian outsiders Dnipro Dnipropetrovsk in Wednesday's Europa League final.
Villarreal's struggles in the Spanish league continued with a 2-1 loss at Athletic Bilbao, with striker Gerard Moreno not finishing the game because of an injury.
A summary of Saturday's action in the Premier League.
Karim Benzema's hat-trick earned Real Madrid a 3-1 win at reigning European champions Chelsea in their Champions League quarter-final first leg on Wednesday. In another quarter-final match, Villarreal stunned six times European Cup winners Bayern Munich 1-0.
Leandro Trossard transformed the mood at Arsenal with the winning goal as they recovered from an early setback to beat Tottenham Hotspur 2-1 at home.
The defeat halted Brighton's impressive three-game winning streak which included a 4-1 win over Chelsea and a 3-1 victory at Arsenal in the League Cup on Wednesday.
While Spurs play Inter Milan at home in Champions League on Wednesday, on Thursday, Arsenal face a long trip to Ukraine to play Vorskla Poltava in the Europa League, needing a victory to consolidate first place in the group.
News of all that's transpired on and off the football field
Arsenal substitute Pierre-Emerick Aubameyang scored twice in three minutes and captain Mesut Ozil played a starring role as they extended their winning run with a 3-1 victory over Leicester City in the Premier League on Monday.
Wenger departed in May after 22 years in charge having endured a barrage of criticism in the latter part of his reign for a tactical approach that resulted in 14 seasons without a Premier League title.
Liverpool coach Juergen Klopp had praised Spanish clubs on the eve of the match, saying they had better scouting, coaches and player development than their English, German and Italian equivalents.
Leeds United's Premier League relegation fears heightened as they slipped to a 2-1 defeat at Aston Villa on Friday, leaving Jesse Marsch's side without a win in their last seven games in all competitions.
There will be no seismic shifts in the balance of the world's richest football competition if the first weekend of the new Premier League season is anything to go by.
IMAGES from the EPL match played between Arsenal and Newcastle on Monday
Real Madrid will be without forward pair Cristiano Ronaldo and Gareth Bale, midfielder Toni Kroos and defender Pepe for Tuesday's UEFA Super Cup encounter with Sevilla in Trondheim, Norway.
News of all that's transpired on and off the football field
